Reducing Biological Age Using Transfer Factor

Russian University of People’s Friendship, Moscow, Russia National Gerontolgical Centre, Laboratory for Gerontology MGSU (Moscow State University of Dentistry), Moscow, Russia

Immunological reactivity of people living in big cities is characterized by high occurrence of ecologically induced secondary immunodeficits. Irreversible changes in the immune system lead to exhaustion of reserves and development of a pathology. The close interaction is known between decline in functional activity of the immune system and the process of aging. Therefore it seems feasible to explore the influence of perspective immunomodulators on the parameters of the biological age.

There is a concept of the role of a special subpopulation of T-lymphocytes for maintenance of cell growth in the body and consequently lowering its function for aging. Raising the function of such cells – the way to a therapy of aging is possible due to Transfer Factor from 4Life (USA). Transfer Factor is a new highly effective product for supporting the immune system and protecting the body from numerous hazardous factors.

Female mice Balb/c aged 12 months were given Transfer Factor physiological salt solution one time daily during a week, the dose was identical to the one given to people. As a test of cell growth potential a hyperplastic reaction of the tissues of salivary glands on isoproterenol was used (mass increase in 24 hours). Under observation also were: masses of thymus and spleen, the amount of mononuclears secreted by the spleen with ficoll density gradient 1,09 (lymphocytes + A-cells) and density 1,065 (activated spleen cells with reduced density) as well as an amount of A-cells in the spleen (adjusted to the surface of plastic Petri cups).

It was revealed that if in young mice administration of isoproterenol causes an increase in the mass of salivary glands of 1,6-1,8 times, whereas in old mice reduction of the mass was demonstrated. Administering of Transfer Factor restored the potential of cell proliferation in old mice – use of isoproterenol resulted in mass increase of 1,5-1,7 times! At the same time the amount of activated spleen cells was dramatically (in several times) increased and also inhibition of thymus stress reaction (reduction of mass) under the effect of adrenomimetics – isoproterenol was reported. A number of modifications of A-cells were also observed.

Transfer Factor effect on aging processes was studied in 12 men aged 55-73. The examinations were carried out twice – before and after taking Transfer Factor. The preparation was given on the following scheme: 300 mg a day 5 times a week during 6 weeks. The parameters of the biological age were assessed with the help of the program Diagnostics of aging: biological age developed by the National gerontology center, Moscow. Biomarkers used for estimation: arterial blood pressure, speed of pulse wave, vital capacity of the lungs, static balance, Shtange probe, accommodation, body weight, strength in the left hand, Shulte test, Vecksler test, neuromusclular test, upper limit of hearing, a health self-assessment questionnaire. The activity of the functional body systems was determined with the help of electroakupunture diagnostics Nakatani.

The average calendar age in the group was 63,5 ± 0,7 years. Before administering Transfer Factor the difference between the calendar age and the average biological age in the group was (-4,2) ± 0,6 (in the range of +0,5–6,6). In most men reduction of functional activity of the endocrine and immune system as well as hyperfunction of lever and bladder and pancreas hypofunction were stated.

After the Transfer Factor course difference between the biological and calendar age came to (–8,2) ± 0.5 (p<0.05). Normalization of activity in affected body systems was observed.

The preliminary investigation let us view Transfer Factor as an effective geroprotector enabling to regulate aging processes.